New Biotransformation Products of Nemadectins.
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چکیده
منابع مشابه
New biotransformation products of nemadectins.
Selected nemadectins (formerly LL-F28249 series) have been fed to a panel of microorganisms with the aim of generating new derivatives. In addition to products resulting from the oxidation of the terminal methyl group (C-29), a unique phosphorylated nemadectin was isolated. The phosphate group was determined to be at C-23 by HMBC between phosphorus and H-23. Milbemycin or nemadectin derivatives...
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In order to mimic the human metabolic pathway of cyclosporin A (CyA) a total of 28 bacterial and 72 fungal strains was screened for their ability to transform CyA. Among 3 bacteria and 11 fungi, which produced the main human metabolite OL-17 [eta HyMeBmt1]CyA, Actinoplanes sp. (ATCC 53771) achieved the best transformation rate (5.4%). Furthermore, the two N-demethylated minor products [Leu4]CyA...
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The products of microbial transformation of 2,4-dinitrotoluene by Mucrosporium sp. were identified by thin-layer chromatography and by gas chromatography/mass spectrometry as 2-amino-4-nitrotoluene, 4-amino-2-nitrotoluene, 2,2'-dinitro-4,4'-azoxytoluene, 4,4'-dinitro-2,2'-azoxytoluene, and 4-acetamido-2-nitrotoluene. A third azoxy compound, believed to be a "mixed" type (i.e., 2,4'-azoxy or 4,2...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2001
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.54.805